Molecular structure and biological function of alpha-fetoprotein
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms of alpha-fetoprotein gene expression.
Alpha-fetoprotein (AFP) is the main component of mammalian fetal serum. It is synthesized by visceral endoderm of the yolk sac and by fetal liver. Immediately after birth AFP level in blood decreases dramatically. AFP synthesis is reactivated in liver tumors and germinogeneous teratoblastomas, in a lesser degree after chemical and mechanical liver injuries followed by regeneration (i.e., acute ...
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Alpha-fetoprotein (AFP), a serum glycoprotein belonging to the onco-developmental proteins group, serves as a marker both in cancer research and in studies concerning fetal development and fetal pathophysiology. Monoclonal anti-AFP antibodies are essential reagents in developing appropriate techniques for measurement of this protein. In this study, in order to produce anti-AFP monoclonal a...
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alpha-Fetoprotein (AFP) is a tumor-associated Ag, and its serum level is elevated in patients with hepatocellular carcinoma (HCC). In vitro, AFP induces functional impairment of dendritic cells (DCs). This was demonstrated by the down-regulation of CD40 and CD86 molecules and the impairment of allostimulatory function. Also, AFP was found to induce significant apoptosis of DCs, and AFP-treated ...
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..................................................................................................................................... 1 Zusammenfassung ...................................................................................................................... 3 Chapter 1. General Introduction ...............................................................................................
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ژورنال
عنوان ژورنال: World Chinese Journal of Digestology
سال: 2014
ISSN: 2219-2859
DOI: 10.11569/wcjd.v22.i11.1487